Increased rejection of primary tumors in mice lacking B cells: inhibition of anti-tumor CTL and TH1 cytokine responses by B cells.

@article{Shah2005IncreasedRO,
  title={Increased rejection of primary tumors in mice lacking B cells: inhibition of anti-tumor CTL and TH1 cytokine responses by B cells.},
  author={S. M. Ibrahim Shah and Anagha A. Divekar and Shannon P. Hilchey and H. Cho and Corliss L Newman and Seung-uon Shin and Hovav Nechustan and Pia M. Challita-Eid and Benjamin M Segal and Kyung Hee Yi and Joseph D. Rosenblatt},
  journal={International journal of cancer},
  year={2005},
  volume={117 4},
  pages={574-86}
}
We investigated the role of B cells in tumor immunity by studying immune responses of mice genetically lacking B cells to primary tumors. IgM(-/-) B cell-deficient mice (BCDM) exhibited enhanced resistance to 3 histologically diverse syngeneic tumors as compared to the wild-type (WT) mice. EL4 thymoma and MC38 colon carcinoma grew progressively in WT mice, but regressed spontaneously in BCDM whereas growth of B16 melanoma was slowed significantly in BCDM as compared to the WT mice. BCDM… CONTINUE READING