Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.

@article{Fecci2006IncreasedRT,
  title={Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.},
  author={Peter Edward Fecci and Duane A. Mitchell and John F. Whitesides and Weihua Xie and Allan H. Friedman and Gary E. Archer and James E. Herndon and Darell D Bigner and Glenn Dranoff and John H. Sampson},
  journal={Cancer research},
  year={2006},
  volume={66 6},
  pages={3294-302}
}
Immunosuppression is frequently associated with malignancy and is particularly severe in patients with malignant glioma. Anergy and counterproductive shifts toward T(H)2 cytokine production are long-recognized T-cell defects in these patients whose etiology has remained elusive for >30 years. We show here that absolute counts of both CD4(+) T cells and CD4(+)CD25(+)FOXP3(+)CD45RO(+) T cells (T(regs)) are greatly diminished in patients with malignant glioma, but T(regs) frequently represent an… CONTINUE READING
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