Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells.

@article{Young1997IncreasedRA,
  title={Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells.},
  author={M Rita I Young and Mark A. Wright and Yvonne Lozano and M. Margaret Prechel and Justin D. Benefield and John P. Leonetti and Samuel Collins and Guy Joseph Petruzzelli},
  journal={International journal of cancer},
  year={1997},
  volume={74 1},
  pages={69-74}
}
Human head and neck squamous cell carcinomas (HNSCC) that produce high levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) have been shown to contain CD34+ natural suppressor cells that inhibit the activity of intratumoral T-cells. The present study evaluated whether GM-CSF production and the presence of CD34+ cells within primary HNSCC would translate into increased recurrence, metastasis or cancer-related death during the 2 years following surgical excision. Freshly excised… CONTINUE READING
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