Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.

@article{Ahmed2000IncreasedRO,
  title={Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.},
  author={M Said Ahmed and W Y Hung and James S. Zu and Philip E. Hockberger and Teepu Siddique},
  journal={Journal of the neurological sciences},
  year={2000},
  volume={176 2},
  pages={88-94}
}
Amyotrophic lateral sclerosis (ALS) is a paralytic disorder characterized by degeneration of large motor neurons of the brain and spinal cord. A subset of ALS is inherited (familial ALS, FALS) and is associated with more than 70 different mutations in the SOD1 gene. Here we report that lymphoblast cell lines derived from FALS patients with 16 different mutations in SOD1 gene exhibit significant increase of intracellular reactive oxygen species (ROS) compared with sporadic ALS (SALS) and normal… CONTINUE READING

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