Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse.

@article{Gervasio2005IncreasedRO,
  title={Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse.},
  author={Othon L. Gervasio and William D. Phillips},
  journal={The Journal of physiology},
  year={2005},
  volume={562 Pt 3},
  pages={
          673-85
        }
}
The metabolic turnover of nicotinic ACh receptors (AChR) at the neuromuscular synapse is regulated over a tenfold range by innervation status, muscle electrical activity and neural agrin, but the downstream effector of such changes has not been defined. The AChR-associated protein rapsyn is essential for forming AChR clusters during development. Here, rapsyn was tagged with enhanced green fluorescent protein (EGFP) to begin to probe its influence at the adult synapse. In C2 myotubes, rapsyn… CONTINUE READING
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Dynamics of the rapsyn scaffolding protein at the neuromuscular junction of live mice.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2010
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