Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats.

@article{Luiken2001IncreasedRO,
  title={Increased rates of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats.},
  author={Joost J. F. P. Luiken and Yoga Arumugam and David James Dyck and Rhonda C Bell and Maurice M. A. L. Pelsers and Lorraine P. Turcotte and Narendra N. Tandon and Jan F. C. Glatz and Arend Bonen},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 44},
  pages={40567-73}
}
Giant vesicles were used to study the rates of uptake of long-chain fatty acids by heart, skeletal muscle, and adipose tissue of obese and lean Zucker rats. With obesity there was an increase in vesicular fatty acid uptake of 1.8-fold in heart, muscle and adipose tissue. In some tissues only fatty acid translocase (FAT) mRNA (heart, +37%; adipose, +80%) and fatty acid-binding protein (FABPpm) mRNA (heart, +148%; adipose, +196%) were increased. At the protein level FABPpm expression was not… CONTINUE READING

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