Increased rate of deleterious variants in long runs of homozygosity of an inbred population from Qatar.

OBJECTIVE The aim of this study is to evaluate the fraction of putatively deleterious variants within genomic runs of homozygosity (ROH) regions in an inbred and selected cohort of Qatari individuals. METHODS High-density SNP array analysis was performed in 36 individuals, and for 14 of them whole-exome sequencing (WES) was also carried out. RESULTS In… CONTINUE READING