Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process.

@article{ODonnell1995IncreasedRO,
  title={Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process.},
  author={Brian F. O'Donnell and Steven F. Faux and R. W. McCarley and Matthew O. Kimble and Dean F. Salisbury and Paul Nestor and Ron Kikinis and Ferenc A. Jolesz and Martha Elizabeth Shenton},
  journal={Archives of general psychiatry},
  year={1995},
  volume={52 7},
  pages={544-9}
}
BACKGROUND The latency of the P300 event-related potential is prolonged in disorders associated with neural damage and degeneration and also becomes prolonged in the course of neural changes that accompany aging. We tested whether the rate of P300 latency increase with age was greater in male schizophrenic patients than in normal subjects because a steeper slope in schizophrenia would suggest a progressive neurodegenerative process. We also evaluated a subset of these subjects for changes in… CONTINUE READING

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