Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression.

@article{Samid1991IncreasedRR,
  title={Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression.},
  author={Dvorit Samid and Alexandra C Miller and Donata Rimoldi and J{\"u}rg Gafner and Edward P. Clark},
  journal={Radiation research},
  year={1991},
  volume={126 2},
  pages={244-50}
}
The cellular Ha-ras oncogene, activated by missense mutations, has been implicated in intrinsic resistance to ionizing radiation. This study shows that the overexpression of the unmutated gene (proto-oncogene) may also be involved in how the cells respond to radiation. The experimental system consisted of mouse NIH 3T3-derived cell lines which carry multiple copies of a transcriptionally activated human c-Ha-ras proto-oncogene. Both tumorigenic (RS485) and revertant nontumorigenic subclones… CONTINUE READING
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