Increased psychological responses and divergent neuroendocrine responses to m-CPP and ipsapirone in patients with panic disorder.

@article{Broocks2000IncreasedPR,
  title={Increased psychological responses and divergent neuroendocrine responses to m-CPP and ipsapirone in patients with panic disorder.},
  author={Andreas Broocks and Borwin Bandelow and Abraham George and C Jestrabeck and Martin Opitz and Uwe Bartmann and Christoph H. Gleiter and Ingolf Meineke and I S Roed and Eckart Ruether and Goeran Hajak},
  journal={International clinical psychopharmacology},
  year={2000},
  volume={15 3},
  pages={153-61}
}
In patients with panic disorder and /or agoraphobia (PDA) an increased sensitivity of central 5-HT2C receptors and a decreased responsiveness of 5-HT1A receptors has been postulated. In the present study, neuroendocrine challenges were performed using oral doses of the non-selective 5-HT2C agonist m-chlorophenylpiperazine (m-CPP) (0.4 mg/kg), the selective 5-HT1A antagonist ipsapirone (0.3 mg/kg), and placebo in 40 patients with PDA and 12 healthy controls in order to compare 5-HT2C and 5-HT1A… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…