Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.

@article{Chen2005IncreasedPA,
  title={Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.},
  author={Li Chen and Kiran Madura},
  journal={Cancer research},
  year={2005},
  volume={65 13},
  pages={5599-606}
}
The ubiquitin (Ub)/proteasome pathway facilitates the degradation of damaged proteins and regulators of growth and stress response. The activation of this pathway in various cancers and malignancies has been described, and several genetic determinants of breast cancer, including BRCA1 and BRCA2, are linked to protein degradation. To investigate the involvement of the Ub/proteasome system in breast cancer, we examined a collection of 25 patient-matched breast cancer and normal adjacent tissues… CONTINUE READING

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Cancer chemoprevention by targeting proteasomal degradation: commentary re KA Dragnev et al, Specific chemopreventive agents Breast Cancer and the Ub/Proteasome System www.aacrjournals.org

  • CS Yang, KV Chin, JD. Lambert
  • Cancer Res
  • 2005

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