Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.

@article{Wu2007IncreasedPC,
  title={Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.},
  author={C Wu and Saleh Altuwaijri and William A. Ricke and Shu-Pin Huang and Shuyuan Yeh and Caixia Zhang and Yuanjie Niu and Meng-Ying Tsai and Chawnshang Chang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 31},
  pages={12679-84}
}
Developmental studies of the prostate have established that ductal morphogenesis, epithelial cytodifferentiation, and proliferation/apoptosis are regulated by androgens acting through stromal androgen receptor (AR). Here, we found mice lacking epithelial AR within the mature prostate (pes-ARKO) developed prostate tissue that was less differentiated and hyperproliferative relative to WT littermates. Epithelial AR protein was significantly decreased in 6-week-old mice and was nearly absent by… CONTINUE READING

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