Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis.

  title={Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis.},
  author={Jawahar L. Mehta and Daniel Lawson and Paulette Mehta and Tom G.P. Saldeen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={85 12},
  • J. Mehta, D. Lawson, T. Saldeen
  • Published 1 June 1988
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
It has been proposed that atherosclerotic arteries produce less prostacyclin (PGI2) than nonatherosclerotic arteries do, thereby predisposing arteries to vasospasm and thrombosis in vivo. We reexamined this concept by measuring spontaneous as well as arachidonate-induced PGI2 biosynthesis in aortic segments from nonatherosclerotic and cholesterol-fed atherosclerotic New Zealand White rabbits. Thromboxane A2 (TXA2) generation was also measured. Formation of PGI2, as well as TXA2, as measured by… 
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