Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection.

Abstract

Prion disease pathogenesis is linked to the cell-associated propagation of misfolded protease-resistant conformers (PrP) of the normal cellular prion protein (PrP). Ongoing PrP expression is the only known absolute requirement for successful prion disease transmission and PrP propagation. Further typifying prion disease is selective neuronal dysfunction and… (More)
DOI: 10.1097/NEN.0b013e3181b96981

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