Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

@article{Miyamoto2002IncreasedPO,
  title={Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ},
  author={Akitomo Miyamoto and Keiko Nakayama and Hiroyuki Imaki and S. Hirose and Yi Jiang and Masaaki Abe and Tadasuke Tsukiyama and Hiroyasu Nagahama and Shigeo Ohno and Shigetsugu Hatakeyama and Keiichi I Nakayama},
  journal={Nature},
  year={2002},
  volume={416},
  pages={865-869}
}
Protein kinase C (PKC), which comprises 11 closely related isoforms, has been implicated in a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis and tumour development. Among the PKC isotypes, PKC-δ is unique in that its overexpression results in inhibition of cell growth. Here we show that mice that lack PKC-δ exhibit expansion of the B-lymphocyte population with the formation of numerous germinal centres in the absence of stimulation. The rate of… CONTINUE READING