Increased prolactin response to buspirone in chronic fatigue syndrome.

  title={Increased prolactin response to buspirone in chronic fatigue syndrome.},
  author={Michael Sharpe and Alison Clements and Keith Hawton and Allan Hunter Young and Phillip Sargent and Philip J. Cowen},
  journal={Journal of affective disorders},
  volume={41 1},
We studied the endocrine and subjective responses that followed acute administration of the 5-HT1A receptor agonist buspirone (0.5 mg/kg orally) in 11 male patients with chronic fatigue syndrome (CFS) and a group of matched healthy controls. Patients with CFS had significantly higher plasma prolactin concentrations and experienced more nausea in response to buspirone than did controls. However, the growth hormone response to buspirone did not distinguish CFS patients from controls. Our data… CONTINUE READING