Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study.

@article{Hanley2002IncreasedPL,
  title={Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study.},
  author={Anthony J. G. Hanley and Ralph B. D'Agostino and Lynne E. Wagenknecht and Mohammed F. Saad and Peter J. Savage and Richard N Bergman and Steven M. Haffner},
  journal={Diabetes},
  year={2002},
  volume={51 4},
  pages={1263-70}
}
Previous studies have indicated that beta-cell dysfunction predicts the development of diabetes, although it is unknown whether the use of combinations of insulin secretory measures further improves prediction. The Insulin Resistance Atherosclerosis Study is a prospective, multicenter, epidemiological study of the relationship between insulin sensitivity and the risk of diabetes and cardiovascular disease. At baseline, fasting concentrations of insulin, intact proinsulin (PI), and split PI were… CONTINUE READING

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Proinsulin levels predict the development of non-insulin dependent diabeA.J.G

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  • HANLEY AND ASSOCIATES DIABETES,
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