Increased production of sonic hedgehog by ballooned hepatocytes.

  title={Increased production of sonic hedgehog by ballooned hepatocytes.},
  author={Fatima A Rangwala and Cynthia D. Guy and Jiuyi Lu and Ayako Suzuki and James L. Burchette and Manal F. Abdelmalek and Wei Chen and Anna Mae Diehl},
  journal={The Journal of pathology},
  volume={224 3},
Ballooned hepatocytes distinguish non-alcoholic steatohepatitis (NASH) from steatosis. Such cells contain dilated endoplasmic reticulum and ubiquitin aggregates, characteristics of endoplasmic reticulum stress. Hepatocyte ballooning increases the risk for fibrosis in NASH, suggesting that ballooned hepatocytes release pro-fibrogenic factors. Hedgehog… CONTINUE READING