Increased production of penicillin-binding protein 2, increased detection of other penicillin-binding proteins, and decreased coagulase activity associated with glycopeptide resistance in Staphylococcus aureus.

@article{Moreira1997IncreasedPO,
  title={Increased production of penicillin-binding protein 2, increased detection of other penicillin-binding proteins, and decreased coagulase activity associated with glycopeptide resistance in Staphylococcus aureus.},
  author={Bernardo Luis Moraes Moreira and Susan Boyle-Vavra and Boudewijn L. deJonge and Robert S. Daum},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 8},
  pages={1788-93}
}
The mechanism of glycopeptide resistance in the genus Staphylococcus is unknown. Since these antimicrobial compounds act by binding the peptidoglycan precursor terminus, the target of transglycosylase and transpeptidase enzymes, it was hypothesized that resistance might be mediated in Staphylococcus aureus by increased production or activity of these enzymes, commonly called penicillin-binding proteins (PBPs). To evaluate this possibility, glycopeptide-resistant mutants were prepared by passage… CONTINUE READING

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