Increased production of human granulocyte-macrophage colony stimulating factor (hGM-CSF) by the addition of stabilizing polymer in plant suspension cultures.

@article{Lee2002IncreasedPO,
  title={Increased production of human granulocyte-macrophage colony stimulating factor (hGM-CSF) by the addition of stabilizing polymer in plant suspension cultures.},
  author={J. Lee and Nan-Sun Kim and Tae-Ho Kwon and Yong-Suk Jang and Moon-sik Yang},
  journal={Journal of biotechnology},
  year={2002},
  volume={96 3},
  pages={205-11}
}
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein that stimulates the production of granulocytes, macrophages, and white blood cells. Secretion of human GM-CSF from cell suspension cultures of genetically modified tobacco has been facilitated using natural mammalian leader sequences. At the mid-exponential growth phase (day 4 after the initiation of cell suspension culture), GM-CSF was detected in the medium at a maximum concentration of 180 microg l(-1). However, the… CONTINUE READING
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