Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2.

@article{Sato2001IncreasedPO,
  title={Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2.},
  author={Naoaki Sato and Kazunori Imaizumi and Tomofumi Manabe and Miyako Taniguchi and Jun Hitomi and Taiichi Katayama and Toshi Yoneda and T. Morihara and Yuichi Yasuda and Tomoko Takagi and Takashi Kudo and Takeshi Tsuda and Y. Itoyama and Takao Makifuchi and Paul E. Fraser and Peter St George-Hyslop and Masaya Tohyama},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 3},
  pages={2108-14}
}
An alternative spliced form of the presinilin 2 (PS2) gene (PS2V) lacking exon 5 has previously been reported to be expressed in human brains in sporadic Alzheimer's disease (AD). PS2V encodes the amino-terminal portion of PS2, which contains residues Met1-Leu119 and 5 additional amino acid residues (SSMAG) at its carboxyl terminus. Here we report that PS2V… CONTINUE READING