Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.

@article{Miyake2001IncreasedPO,
  title={Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.},
  author={Jon H. Miyake and X D Doung and William Strauss and Gina L. Moore and Lawrence W. Castellani and Linda K. Curtiss and John C. Taylor and Roger A. Davis},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 26},
  pages={23304-11}
}
The finding that expression of a cholesterol 7alpha-hydroxylase (CYP7A1) transgene in cultured rat hepatoma cells caused a coordinate increase in lipogenesis and secretion of apoB-containing lipoproteins led to the hypothesis that hepatic production of apoB-containing lipoproteins may be linked to the expression of CYP7A1 (Wang, S.-L., Du, E., Martin, T. D., and Davis, R. A. (1997) J. Biol. Chem. 272, 19351-19358). To examine this hypothesis in vivo, a transgene encoding CYP7A1 driven by the… CONTINUE READING
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