Increased procoagulant activity of red blood cells from patients with homozygous sickle cell disease and beta-thalassemia.

@article{Helley1996IncreasedPA,
  title={Increased procoagulant activity of red blood cells from patients with homozygous sickle cell disease and beta-thalassemia.},
  author={Dominique Helley and Amiram Eldor and Robert Girot and Rolande Ducrocq and Marie Claude Guillin and Annie Bezeaud},
  journal={Thrombosis and haemostasis},
  year={1996},
  volume={76 3},
  pages={322-7}
}
It has recently been proved that, in vitro, red blood cells (RBCs) from patients with homozygous beta-thalassemia behave as procoagulant cells. The procoagulant activity of beta-thalassemia RBCs might be the result of an increased exposure of procoagulant phospholipids (i.e. phosphatidylserine) in the outer leaflet of the membrane. In order to test this hypothesis, we compared the catalytic properties of RBCs of patients with beta-thalassemia and homozygous sickle cell disease (SS-RBCs) with… CONTINUE READING

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In order to test this hypothesis , we compared the catalytic properties of RBCs of patients with beta - thalassemia and homozygous sickle cell disease ( SS - RBCs ) with that of controls .
No significant difference was observed between SS - RBCs and beta - thalassemia RBCs .
In order to test this hypothesis , we compared the catalytic properties of RBCs of patients with beta - thalassemia and homozygous sickle cell disease ( SS - RBCs ) with that of controls .
No significant difference was observed between SS - RBCs and beta - thalassemia RBCs .
No significant difference was observed between SS - RBCs and beta - thalassemia RBCs .
In order to test this hypothesis , we compared the catalytic properties of RBCs of patients with beta - thalassemia and homozygous sickle cell disease ( SS - RBCs ) with that of controls .
No significant difference was observed between SS - RBCs and beta - thalassemia RBCs .
In order to test this hypothesis , we compared the catalytic properties of RBCs of patients with beta - thalassemia and homozygous sickle cell disease ( SS - RBCs ) with that of controls .
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