Increased prevalence of immunoglobulin A deficiency in patients with the chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome).

@article{Smith1998IncreasedPO,
  title={Increased prevalence of immunoglobulin A deficiency in patients with the chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome).},
  author={Craig A Smith and Deborah Anne Driscoll and Beverly S Emanuel and Donna M McDonald-McGinn and E H Zackai and Kathleen E Sullivan},
  journal={Clinical and diagnostic laboratory immunology},
  year={1998},
  volume={5 3},
  pages={415-7}
}
We wished to determine the prevalence of immunoglobulin A (IgA) deficiency in patients with the chromosome 22q11.2 deletion syndrome. A total of 32 patients with the chromosome 22q11.2 deletion were examined for IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in this population is 14.20 (P < 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodeficiency. 

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