Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis.

Abstract

UNLABELLED Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disorder that can progress to cirrhosis, shortening life expectancy. PBC patients are often asymptomatic, present with biochemical cholestasis, and test positive (>or=90%) for antimitochondrial antibodies (AMAs) in serum. Although AMA positivity without biochemical cholestasis may… (More)

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