Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity.

@article{Cipolla2014IncreasedPT,
  title={Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity.},
  author={Marilyn J. Cipolla and Julie G. Sweet and Siu-Lung Chan and Matthew J Tavares and Natalia I. Gokina and Joseph E. Brayden},
  journal={Journal of applied physiology},
  year={2014},
  volume={117 1},
  pages={53-9}
}
Brain parenchymal arterioles (PAs) are high-resistance vessels that branch off pial arteries and perfuse the brain parenchyma. PAs are the target of cerebral small vessel disease and have been shown to have greater pressure-induced tone at lower pressures than pial arteries. We investigated mechanisms by which brain PAs have increased myogenic tone compared with middle cerebral arteries (MCAs), focusing on differences in vascular smooth muscle (VSM) calcium and ion channel function. The amount… CONTINUE READING

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