Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis.

@article{MartnezTorres2004IncreasedPO,
  title={Increased presence of matrix metalloproteinases 2 and 9 in short- and long-term experimental herpes simplex virus encephalitis.},
  author={Francisco J Mart{\'i}nez-Torres and Simone Wagner and Juergen Haas and Roland Kehm and Johann Sellner and Werner Hacke and Uta Meyding-Lamad{\'e}},
  journal={Neuroscience letters},
  year={2004},
  volume={368 3},
  pages={274-8}
}
Herpes simplex virus encephalitis (HSVE) causes elevated morbidity and mortality despite antiviral treatment. Virus-independent mechanisms may perpetuate brain damage. Matrix metalloproteinases (MMPs) target extracellular matrix components. This study describes the protein and mRNA expression of MMP2 and MMP9 in experimental HSVE in the short and long term. Ten SJL-NBOM mice were infected with neurovirulent HSV-1 and compared with nine controls. The presence of MMP2 and MMP9 in brain tissue was… CONTINUE READING