Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase.

Abstract

Human immunodeficiency virus type 1 (HIV-1) variants with resistance mutations in the reverse transcriptase (RT) gene appear during drug therapy with the nucleoside analogue 2',3'-dideoxy-3'-thiacytidine (3TC). These 3TC-resistant RT variants have a single point mutation that changes the 184Met residue into either Val or Ile. Both codon 184 variants are… (More)

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@article{Essink1997IncreasedPF, title={Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase.}, author={B B Oude Essink and N K Back and Bart Berkhout}, journal={Nucleic acids research}, year={1997}, volume={25 16}, pages={3212-7} }