Increased polymerase fidelity of lamivudine-resistant HIV-1 variants does not limit their evolutionary potential.

@article{Keulen1999IncreasedPF,
  title={Increased polymerase fidelity of lamivudine-resistant HIV-1 variants does not limit their evolutionary potential.},
  author={Wilco Keulen and Albert C W A van Wijk and Rob Schuurman and Ben Berkhout and Charles A. Boucher},
  journal={AIDS},
  year={1999},
  volume={13 11},
  pages={1343-9}
}
OBJECTIVE Anti HIV-1 therapy with nucleoside reverse transcriptase inhibitors can select for drug-resistant reverse transcriptase variants with altered enzyme properties. Some of the mutations, e.g. Met184Val and Met184Ile, result in an increase in polymerase fidelity of the enzyme as measured in biochemical assays; however, the effect of such changes on… CONTINUE READING