Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

@article{Muiras1998IncreasedPP,
  title={Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians},
  author={Marie-Laure Muiras and Marcus M{\"u}ller and François Sch{\"a}chter and Alexander B{\"u}rkle},
  journal={Journal of Molecular Medicine},
  year={1998},
  volume={76},
  pages={346-354}
}
Abstract Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins which is catalyzed by poly(ADP-ribose) polymerase and represents an immediate response of eukaryotic cells to oxidative and other types of DNA damage. Previously a strong correlation had been detected between maximal poly(ADP-ribose) polymerase activity in permeabilized mononuclear leukocytes of various mammalian species and species-specific life span. To study a possible relation between longevity and poly… Expand
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  • Annals of the New York Academy of Sciences
  • 2000
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