Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

  title={Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians},
  author={M. Muiras and M. M{\"u}ller and F. Sch{\"a}chter and A. Bürkle},
  journal={Journal of Molecular Medicine},
  • M. Muiras, M. Müller, +1 author A. Bürkle
  • Published 1998
  • Biology, Medicine
  • Journal of Molecular Medicine
  • Abstract Poly(ADP-ribosyl)ation is a posttranslational modification of nuclear proteins which is catalyzed by poly(ADP-ribose) polymerase and represents an immediate response of eukaryotic cells to oxidative and other types of DNA damage. Previously a strong correlation had been detected between maximal poly(ADP-ribose) polymerase activity in permeabilized mononuclear leukocytes of various mammalian species and species-specific life span. To study a possible relation between longevity and poly… CONTINUE READING
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