Increased platelet-derived growth factor production and intimal thickening during healing of Dacron grafts in a canine model.

@article{Margolin1993IncreasedPG,
  title={Increased platelet-derived growth factor production and intimal thickening during healing of Dacron grafts in a canine model.},
  author={David A. Margolin and Boris Kaufman and D Deluca and Paul L. Fox and Linda M Graham},
  journal={Journal of vascular surgery},
  year={1993},
  volume={17 5},
  pages={
          858-66; discussion 866-7
        }
}
PURPOSE Growth factor production by endothelial cells on grafts may play a role in the development of intimal hyperplasia and subsequent graft failure. METHODS To study the relationship between platelet-derived growth factor production and graft healing, 26 beagles underwent placement of 20 cm long, 6 mm internal diameter, knitted Dacron thoracoabdominal grafts, either seeded with autologous endothelial cells (n = 14) or unseeded controls (n = 12). The grafts and adjacent arteries were… CONTINUE READING
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