Increased platelet activity after termination of prostacyclin infusion into man.

@article{Dembiskakie1981IncreasedPA,
  title={Increased platelet activity after termination of prostacyclin infusion into man.},
  author={A. Dembińska-kie{\'c} and Ann M. Zmuda and L Grodzińska and Krzysztof Bieroń and M Basista and Aleksandra Kędzior and Elżbieta Kostka-Trąbka and E Telesz and T Zelazny},
  journal={Prostaglandins},
  year={1981},
  volume={21 5},
  pages={
          827-32
        }
}
Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate.
TLDR
The results indicate that although transient increases in platelet cyclic AMP cause an immediate decrease in platelets responsiveness in vivo or in vitro, a period of enhanced platelet sensitivity follows as platelet cycling AMP falls.
Prostacyclin infusion in acute cerebral infarction
TLDR
Results indicate that prostacyclin can be given safely in doses adequate to suppress platelet function, and encouraged us to proceed with a controlled trial of its clinical efficacy.
Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischaemic stroke.
TLDR
It is concluded that further modified controlled studies are required to evaluate the therapeutic usefulness of PGI2 in the treatment of patients with cerebral ischaemia.
Treatment of ischaemic stroke with prostacyclin.
TLDR
It is considered that an antagonism may exist between endogenous cerebral prostanoids and prostacyClin and may have been responsible for the beneficial effects of prostacyclin therapy.
Tolerance and Pharmacology of Ciprostene, a Stable Epoprostenol (Prostacyclin) Analogue in Humans
TLDR
It is estimated that ciprostene is about 15 times less potent than prostacyclin, and a safe and well‐tolerated dose of cIProstene in healthy subjects is 120 ng/kg/min given for 8 hr/d.
Enhanced Platelet Force Development Despite Drug-Induced Inhibition of Platelet Aggregation in Patients with Thromboanglitis Obliterans
TLDR
The authors report here 2 cases of TAO in which evaluations for hypercoagulable states and of platelet function were performed, and platelet contractile force (PCF) was found to be 82% higher than a normal control in 1 TAO patient and 340%Higher than normal in the second patient.
Double-blind controlled trial of prostacyclin in cerebral infarction.
TLDR
This study has not been able to demonstrate that prostacyclin is effective in the treatment of ischaemic stroke, but due to the sample size the chance of proving this statistically (the power) was small.
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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
TLDR
A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
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