Increased plasma serotonin in primary pulmonary hypertension.

  title={Increased plasma serotonin in primary pulmonary hypertension.},
  author={Philippe Herve and J. M. Launay and M L Scrobohaci and F Brenot and G{\'e}rald Simonneau and Patrick Petitpretz and Patrice Poubeau and Jacques Cerrina and Pierre Duroux and Ludovic Drouet},
  journal={The American journal of medicine},
  volume={99 3},
PURPOSE Pulmonary hypertension can occur in patients who have disorders associated with altered platelet serotonin storage, including collagen vascular disease and platelet storage pool disease. We tested the hypothesis that primary pulmonary hypertension (PPH) may be also associated with impaired handling of serotonin by platelets, resulting in increased plasma serotonin levels. PATIENTS AND METHODS We used radioenzymatic assays to measure serotonin in platelets and plasma and serotonin… CONTINUE READING
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