Increased plasma renin and aldosterone in patients treated with cisplatin-based chemotherapy for metastatic germ-cell tumors.

@article{Bosl1986IncreasedPR,
  title={Increased plasma renin and aldosterone in patients treated with cisplatin-based chemotherapy for metastatic germ-cell tumors.},
  author={George J. Bosl and Silvia Leitner and StevenA. Atlas and JeanE. Sealey and Jacek J. Preibisz and Edward F. Scheiner},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1986},
  volume={4 11},
  pages={
          1684-9
        }
}
Twenty-four normotensive males in complete remission (CR) for 9+ to 54+ months after cisplatin-based chemotherapy for metastatic germ-cell tumors were evaluated for evidence of alterations in the renin-aldosterone axis and renal function. Abnormally high ambulatory plasma renin activity was seen in 14 of 19 patients with 24-hour urine sodium excretion greater than 50 mEq. This was correlated with elevated ambulatory plasma aldosterone (P = .009) and 24-hour urinary aldosterone excretion (P… CONTINUE READING

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