Increased plasma protein homocysteinylation in hemodialysis patients.

  title={Increased plasma protein homocysteinylation in hemodialysis patients.},
  author={Alessandra F Perna and Ersilia Satta and Filomena Acanfora and Cinzia Lombardi and Diego Ingrosso and Natale Gaspare De Santo},
  journal={Kidney international},
  volume={69 5},
Hyperhomocysteinemia, an independent cardiovascular risk factor, is present in the majority of hemodialysis patients. Among the postulated mechanisms of toxicity, protein homocysteinylation is potentially able to cause significant alterations in protein function. Protein homocysteinylation occurs through various mechanisms, among which is the post-translational acylation of free amino groups (protein-N-homocysteinylation, mediated by homocysteine (Hcy) thiolactone). Another type of protein… CONTINUE READING


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