Increased plasma norepinephrine and sympathetic nervous activity in essential hypertensive and uremic humans: effects of clonidine.

@article{Izzo1987IncreasedPN,
  title={Increased plasma norepinephrine and sympathetic nervous activity in essential hypertensive and uremic humans: effects of clonidine.},
  author={Joseph L. Izzo and Richard P. Santarosa and P S Larrabee and Rachel J. Smith and Michael C Kallay},
  journal={Journal of cardiovascular pharmacology},
  year={1987},
  volume={10 Suppl 12},
  pages={S225-9}
}
We investigated the relationship between hypertension and increased sympathoadrenal activity in previously normotensive, stable maintenance hemodialysis patients (uremics) who developed hypertension subsequent to the onset of chronic renal failure. In age-matched groups, supine morning plasma norepinephrine (NE) concentrations (pg/ml) were elevated in uremics (401 +/- 26, p less than 0.00001, n = 23) and essential hypertensives (340 +/- 23, p less than 0.01, n = 29) compared to normal controls… CONTINUE READING