Increased plasma levels of soluble CD40 ligand correlate with platelet activation markers and underline the need for standardized pre-analytical conditions.

@article{Riondino2010IncreasedPL,
  title={Increased plasma levels of soluble CD40 ligand correlate with platelet activation markers and underline the need for standardized pre-analytical conditions.},
  author={Silvia Riondino and Francesca Martini and Francesca La Farina and Antonella Spila and Fiorella Guadagni and Patrizia Ferroni},
  journal={Clinical biochemistry},
  year={2010},
  volume={43 7-8},
  pages={666-70}
}
OBJECTIVES To investigate whether sCD40L dosage might represent a useful tool to explore in vivo platelet function. DESIGN AND METHODS sCD40L and sP-selectin levels and light transmission aggregometry (LTA) were analyzed in 69 healthy donors. Immunoassays were performed on platelet-depleted citrate plasma samples. The effects of in vitro aspirin treatment on the release of sCD40L were investigated in 15 subjects following platelet stimulation. The effects of a 1-month therapeutic course of… CONTINUE READING

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