Increased plasma ghrelin following infliximab in Crohn's disease.

  title={Increased plasma ghrelin following infliximab in Crohn's disease.},
  author={Edmond Z H Sung and Natalino Francisco da Silva and Steve Goodyear and Phillip G McTernan and Gareth John Sanger and Chuka U. Nwokolo},
  journal={Alimentary pharmacology & therapeutics},
  volume={29 1},
BACKGROUND Ghrelin, a potent orexigenic peptide produced by the stomach, may be affected by circulating inflammatory mediators. AIM To assess the effect of an anti-TNFα antibody on ghrelin in patients with Crohn's disease (CD). METHODS Fifteen patients with Crohn's receiving infliximab were studied before and 1 week after infusion. Following an overnight fast, blood was sampled before a meal and then every 20 min for 2 h. Total ghrelin and CRP were measured using ELISA. Acylated ghrelin and… CONTINUE READING


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Ghrelin-a new gastroprotective factor in gastric mucosa.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society • 2004

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