Increased plasma fatty acid ethyl ester levels following inhibition of oxidative metabolism of ethanol by 4-methylpyrazole treatment in human subjects.

@article{Best2006IncreasedPF,
  title={Increased plasma fatty acid ethyl ester levels following inhibition of oxidative metabolism of ethanol by 4-methylpyrazole treatment in human subjects.},
  author={Catherine A. Best and Taisto Sarkola and C. J. Peter Eriksson and Joanne E. Cluette-Brown and Michael Laposata},
  journal={Alcoholism, clinical and experimental research},
  year={2006},
  volume={30 7},
  pages={1126-31}
}
BACKGROUND Recent experimental evidence suggests that fatty acid ethyl esters (FAEE), nonoxidative metabolites of ethanol, mediate ethanol-induced organ damage. A direct association between pancreas-specific toxicity and increased levels of FAEE following inhibition of the oxidative metabolism of ethanol by 4-methylpyrazole (4-MP) has previously been shown in studies with rats. METHODS We obtained plasma samples from 32 healthy human volunteers who drank ethanol following 4-MP or placebo… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Pancreatic injury induced by fatty acid ethyl ester, a non-oxidative metabolite of alcohol

J Werner, M Laposata, +4 authors AL Warshaw
Gastroenterology • 1997
View 4 Excerpts
Highly Influenced

Induction of apoptosis by fatty acid ethyl esters in HepG2 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2005
View 1 Excerpt

Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol.

American journal of physiology. Gastrointestinal and liver physiology • 2002
View 1 Excerpt

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