Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer.

@article{Edgell2010IncreasedPC,
  title={Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer.},
  author={Tracey A. Edgell and Dong L Barraclough and Antonio Raji{\vc} and Janu Dhulia and Kate J. Lewis and Jane E. Armes and Roger Barraclough and Philip S. Rudland and Gregory E Rice and Dominic J. Autelitano},
  journal={Clinical science},
  year={2010},
  volume={118 12},
  pages={
          717-25
        }
}
Ovarian cancer is often asymptomatic and is diagnosed at an advanced stage with poor survival rates, thus there is an urgent need to develop biomarkers for earlier detection of ovarian cancer. In the present study, we demonstrate for the first time that the previously reported metastasis-inducing protein AGR2 (anterior gradient protein 2) can be detected in the blood of ovarian cancer patients. Using a newly developed ELISA, we show significantly increased concentrations of AGR2 protein in… 

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References

SHOWING 1-10 OF 21 REFERENCES

The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients.

Primary tumors from a group of 315 patients suffering from operable (stage I and II) breast cancer with 20-years follow-up were immunocytochemically stained with a specific mAb to AGR2 and associations with prognostic factors and patient survival were analyzed.

Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients

A rabbit antibody to recombinant human AGR2 was used to assess its prognostic significance in a retrospective cohort of 351 breast cancer patients treated by adjuvant hormonal therapy, finding a significant association with patient death over a 10-year period.

Progress and Challenges in Screening for Early Detection of Ovarian Cancer*

There is a sound basis for optimism that further developments in serum proteomic analysis will provide powerful methods for screening in ovarian cancer and many other diseases.

Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma.

Overexpression of AGR2 mRNA was found to be elevated in most pancreatic cell lines and in microdissected pancreatic cancer compared to microdissectioned normal ductal cells, and a prognostic value of A GR2 could not be demonstrated in univariate analyses.

Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival.

In vivo, silencing of AGR2 in MPanc-96 cells led to a significant reduction of tumor growth and increased the effectiveness of gemcitabine treatments in orthotopic tumor models evaluated by noninvasive bioluminescence imaging.

Global gene expression profiling of circulating tumor cells.

A novel approach for the identification of molecular markers to detect and characterize CTCs in peripheral blood and it is shown that gene expression profiles for C TCs may be used to distinguish normal donors from advanced cancer patients as well as to differentiate among the three different metastatic cancers.

Expression Profiling of Mucinous Tumors of the Ovary Identifies Genes of Clinicopathologic Importance

Hierarchical clustering and binary tree prediction analysis revealed increased heterogeneity among mucinous tumors compared with their serous counterparts and genes involved in cytoskeletal regulation were specifically up-regulated in the mucinous adenocarcinomas.

Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomas.

These experiments are the first to link mechanistically the developmental gene product, AGR2, with metastasis in vivo and exhibited enhanced rates of adhesion to a plastic substratum and extracellular A GR2 enhanced the rate of attachment of AGR 2-negative but not AGR1-positive cells.