Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer.

  title={Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer.},
  author={Tracey A. Edgell and Dong L Barraclough and Antonio Raji{\vc} and Janu Dhulia and Kate J. Lewis and Jane E. Armes and Roger Barraclough and Philip S. Rudland and Gregory E Rice and Dominic J. Autelitano},
  journal={Clinical science},
  volume={118 12},
Ovarian cancer is often asymptomatic and is diagnosed at an advanced stage with poor survival rates, thus there is an urgent need to develop biomarkers for earlier detection of ovarian cancer. In the present study, we demonstrate for the first time that the previously reported metastasis-inducing protein AGR2 (anterior gradient protein 2) can be detected in the blood of ovarian cancer patients. Using a newly developed ELISA, we show significantly increased concentrations of AGR2 protein in… 

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