Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer.

@article{Edgell2010IncreasedPC,
  title={Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer.},
  author={Tracey A. Edgell and Dong L Barraclough and Antonio Raji{\vc} and Janu Dhulia and Kate J. Lewis and Jane E. Armes and Roger Barraclough and Philip S. Rudland and Gregory E Rice and Dominic J. Autelitano},
  journal={Clinical science},
  year={2010},
  volume={118 12},
  pages={
          717-25
        }
}
Ovarian cancer is often asymptomatic and is diagnosed at an advanced stage with poor survival rates, thus there is an urgent need to develop biomarkers for earlier detection of ovarian cancer. In the present study, we demonstrate for the first time that the previously reported metastasis-inducing protein AGR2 (anterior gradient protein 2) can be detected in the blood of ovarian cancer patients. Using a newly developed ELISA, we show significantly increased concentrations of AGR2 protein in… 
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Positive serum AGR2 expression was significantly associated with the incidence of recurrence after surgery and with a poor prognosis and might become a clinically useful biomarker for early detection, prediction ofRecurrence and prognosis with lung adenocarcinomas.

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Anterior gradient protein 2 (AGR2) is an independent prognostic factor in ovarian high-grade serous carcinoma

Investigation of the expression pattern and prognostic potential of the metastasis-promoting protein anterior gradient 2 in primary HGSC revealed that AGR2 expression was an independent prognostic marker for OS and PFS and a potential marker for response to platinum-based CTX in this tumor entity.

Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia

It is suggested that elevation of AGR2 levels in pancreatic juice occurs in early pancreatic cancer progression and could be further investigated as a potential candidate juice biomarker for early detection of Pancreatic cancer.

Serum AGR2 as a useful biomarker for pituitary adenomas

The Anterior GRadient (AGR) family proteins in epithelial ovarian cancer

The discovery of the anterior gradient proteins AGR2 and AGR3 attracted researchers’ attention due to their putative involvement in adenocarcinoma development and a better understanding of the role of the AGR family may provide new handling avenues for EOC patients.

Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer

The data obtained in this study confirm that both MDK and AGR2 individually display utility as biomarkers for ovarian cancer and that in a multi-analyte panel significantly improve the diagnostic utility of CA125 in symptomatic women.

AGR2 expression in ovarian tumours: a potential biomarker for endometrioid and mucinous differentiation

The findings indicate that AGR2 expression is associated with mucinous carcinomas and their precursor lesions and endometrioid cancers and may be an important prognostic biomarker of ovarian cancer.

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