Increased plasma amyloid beta protein 1-42 levels in Down syndrome.

  title={Increased plasma amyloid beta protein 1-42 levels in Down syndrome.},
  author={Pankaj D. Mehta and Arthur J. Dalton and Sangita P Mehta and Kwang Soo Kim and Eugene A Sersen and Henryk M. Wiśniewski},
  journal={Neuroscience letters},
  volume={241 1},
Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were… CONTINUE READING
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