Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.

@article{Takano1991IncreasedPO,
  title={Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.},
  author={Hideki Takano and Kimitoshi Kohno and Mitsunori Ono and Yoshikazu Uchida and Michihiko Kuwano},
  journal={Cancer research},
  year={1991},
  volume={51 15},
  pages={3951-7}
}
We have isolated two etoposide (VP16)-resistant cell lines, KB/VP-1 and KB/VP-2, from human cancer KB cells after stepwise exposure to increasing doses of VP16. KB/VP-1 and KB/VP-2 showed 30- and 50-fold higher resistance to VP16 and also 20- and 30-fold higher resistance to teniposide than the parent cell line. Furthermore, both resistant cell lines showed more than 2-fold cross-resistance to Adriamycin and daunomycin than KB cells. The levels of accumulation and outward transport of… CONTINUE READING
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