Increased phosphorylation of Akt in triple-negative breast cancers.

@article{Umemura2007IncreasedPO,
  title={Increased phosphorylation of Akt in triple-negative breast cancers.},
  author={Shinobu Umemura and Sei Yoshida and Yoshikazu Ohta and Kenichiro Naito and Robert Yoshiyuki Osamura and Yutaka Tokuda},
  journal={Cancer science},
  year={2007},
  volume={98 12},
  pages={
          1889-92
        }
}
Cells from breast cancers lacking hormone receptors (estrogen receptor [ER], progesterone receptor [PgR]) and human epidermal growth factor receptor (HER) 2 strongly express the cell proliferation marker Ki-67. However, the mechanisms of and stimulus signals involved in cell proliferation of this type of breast cancer are not well understood. The aim of the present study was to examine the characteristics of signal transduction in triple-negative (ER-, PgR-, and HER2-negative) breast cancers… CONTINUE READING

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