Increased phosphorylation of Akt in triple-negative breast cancers.

@article{Umemura2007IncreasedPO,
  title={Increased phosphorylation of Akt in triple-negative breast cancers.},
  author={Shinobu Umemura and Sei Yoshida and Yoshikazu Ohta and Kenichiro Naito and Robert Yoshiyuki Osamura and Yutaka Tokuda},
  journal={Cancer science},
  year={2007},
  volume={98 12},
  pages={1889-92}
}
Cells from breast cancers lacking hormone receptors (estrogen receptor [ER], progesterone receptor [PgR]) and human epidermal growth factor receptor (HER) 2 strongly express the cell proliferation marker Ki-67. However, the mechanisms of and stimulus signals involved in cell proliferation of this type of breast cancer are not well understood. The aim of the present study was to examine the characteristics of signal transduction in triple-negative (ER-, PgR-, and HER2-negative) breast cancers… CONTINUE READING

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Cells from breast cancers lacking hormone receptors ( estrogen receptor [ ER ] , progesterone receptor [ PgR ] ) and human epidermal growth factor receptor ( HER ) 2 strongly express the cell proliferation marker Ki-67 .
Cells from breast cancers lacking hormone receptors ( estrogen receptor [ ER ] , progesterone receptor [ PgR ] ) and human epidermal growth factor receptor ( HER ) 2 strongly express the cell proliferation marker Ki-67 .
EstrogensContraindicated with diseaseMammary Neoplasms
Cells from breast cancers lacking hormone receptors ( estrogen receptor [ ER ] , progesterone receptor [ PgR ] ) and human epidermal growth factor receptor ( HER ) 2 strongly express the cell proliferation marker Ki-67 .
Hormone ReceptorIs biochemical function of gene productestrogen receptor alpha, human
Cells from breast cancers lacking hormone receptors ( estrogen receptor [ ER ] , progesterone receptor [ PgR ] ) and human epidermal growth factor receptor ( HER ) 2 strongly express the cell proliferation marker Ki-67 .
ProgesteroneContraindicated with diseaseMammary Neoplasms
Cells from breast cancers lacking hormone receptors ( estrogen receptor [ ER ] , progesterone receptor [ PgR ] ) and human epidermal growth factor receptor ( HER ) 2 strongly express the cell proliferation marker Ki-67 .
For 44 tumor samples , western blotting analysis was conducted to examine the phosphorylation of HER2 , external signal - regulated kinase ( ERK)1 and -2 and Akt , and the immunohistochemical phenotypes of the samples with respect to ER and HER2 were also assessed .
For 44 tumor samples , western blotting analysis was conducted to examine the phosphorylation of HER2 , external signal - regulated kinase ( ERK)1 and -2 and Akt , and the immunohistochemical phenotypes of the samples with respect to ER and HER2 were also assessed .
Cells from breast cancers lacking hormone receptors ( estrogen receptor [ ER ] , progesterone receptor [ PgR ] ) and human epidermal growth factor receptor ( HER ) 2 strongly express the cell proliferation marker Ki-67 .
estrogen receptor alpha, humanGene product plays role in biological processCell Proliferation
Cells from breast cancers lacking hormone receptors ( estrogen receptor [ ER ] , progesterone receptor [ PgR ] ) and human epidermal growth factor receptor ( HER ) 2 strongly express the cell proliferation marker Ki-67 .
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