Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome.

@article{Baarends2007IncreasedPA,
  title={Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome.},
  author={Willy M Baarends and Evelyne Wassenaar and Jos W. Hoogerbrugge and Sam Schoenmakers and Zu-Wen Sun and J. Anton Grootegoed},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 11},
  pages={1841-51}
}
Mono-ubiquitylated H2A marks the transcriptionally silenced XY body during male meiotic prophase. Concomitant with H2A(K119ub1), the ubiquitin-conjugating enzyme HR6B is also enriched on the XY body. We analyzed H2A and H2B ubiquitylation in Hr6b-knockout mouse spermatocytes, but no global changes were detected. Next, we analyzed phosphorylation of the threonine residues T120 and T119 that are adjacent to the K119 and K120 target sites for ubiquitylation in H2A and H2B, respectively. In wild… CONTINUE READING

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