Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs.

@article{Gaffey2013IncreasedPP,
  title={Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs.},
  author={Kate Gaffey and Sophie L Reynolds and Jonathan Plumb and Manminder Kaur and Dave Singh},
  journal={The European respiratory journal},
  year={2013},
  volume={42 1},
  pages={28-41}
}
The p38 mitogen-activated protein kinase (MAPK) pathway is upregulated in chronic obstructive pulmonary disease (COPD). To date, dual labelling to identify cell-type-specific presence of phosphorylated (phospho-)p38 MAPK has not been carried out. Phospho-p38 MAPK was quantified in a variety of cell types in the lung tissue of 20 COPD patients, 12 smokers and 12 nonsmokers using immunohistochemistry. Paired blood and sputum neutrophils (from seven subjects with COPD), and CD8 and epithelial… CONTINUE READING
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