Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment.

@article{Song2009IncreasedPA,
  title={Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment.},
  author={Cai Fang Song and Xiang Zhang and Mehar S Manku},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 1},
  pages={14-22}
}
An increased inflammatory response and deficient synthesis of neurotrophic factors (NTFs) may contribute to the etiology of depression. However, the interrelationship between inflammation and NTFs is unknown. Recently, ethyl-eicosapentaenoate (EPA) has been used to treat depression. The mechanism by which EPA benefits depression is also unclear. Using the olfactory bulbectomized (OB) rat model of depression, this study evaluated two pathways from bulbectomy to the induction of depression-like… CONTINUE READING

Citations

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Showing 1-10 of 51 extracted citations

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View 3 Excerpts
Highly Influenced

Cytokines mediated inflammation and decreased neurogenesis in animal models of depression

Progress in Neuro-Psychopharmacology and Biological Psychiatry • 2011
View 14 Excerpts
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View 8 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 80 references

Inflammation, Depression and Dementia: Are they Connected?

Neurochemical Research • 2007
View 5 Excerpts
Highly Influenced

Omega-3 fatty acid EPA reduces inflammation and upregulates neurotrophins in a rodent model of inflammatory neurodegeneration

C Song
Prostaglandins Leukot Essent Fatty Acids, • 2009
View 3 Excerpts
Highly Influenced

Serum concentra

R Hellweg, A Ziegenhorn, I Heuser, M Deuschle
gions of adult rats. Mol Psychiatry • 2008
View 1 Excerpt

Gliogenesis and glial pathology in depression.

CNS & neurological disorders drug targets • 2007
View 2 Excerpts

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