Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.

@article{Antoons2006IncreasedPP,
  title={Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.},
  author={Gudrun Antoons and Peter Vangheluwe and Paul G. A. Volders and Virginie Bito and Patricia Holemans and Marcello Ceci and Frank Wuytack and Pico Caroni and Kanigula Mubagwa and Karin R Sipido},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={40 3},
  pages={
          350-60
        }
}
Reduced Ca(2+) release from the sarcoplasmic reticulum (SR) and a negative force-frequency relation characterize end-stage human heart failure. The MLP(-/-) mouse with dilated cardiomyopathy is used as a model to explore novel therapeutic interventions but the alterations in Ca(2+) handling in MLP(-/-) remain incompletely understood. We studied [Ca(2+)](i) in left ventricular myocytes from MLP(-/-) and WT mice (3-4 months old; whole-cell voltage clamp, 30 degrees C). At 1 Hz stimulation, the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Hearts of surviving MLP-KO mice show transient changes of intracellular calcium handling

  • Molecular and Cellular Biochemistry
  • 2010
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

MLP (muscle LIM protein) as a stress sensor in the heart

  • Pflügers Archiv - European Journal of Physiology
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND