Increased phosphatidylinositol synthesis in rat embryo fibroblasts after growth stimulation and its inhibition by delta-hexachlorocyclohexane.

@article{Hoffmann1980IncreasedPS,
  title={Increased phosphatidylinositol synthesis in rat embryo fibroblasts after growth stimulation and its inhibition by delta-hexachlorocyclohexane.},
  author={R{\'e}my Hoffmann and P Erzberger and Werner Frank and H. J. Ristow},
  journal={Biochimica et biophysica acta},
  year={1980},
  volume={618 2},
  pages={282-92}
}
When resting rat embryo fibroblasts are stimulated to grow, a substantial increase in phosphatidylinositol synthesis can be observed. This increase cannot be explained by increased glucose uptake or glycolysis. delta-Hexachlorocyclohexane having the same configuration as myo-inositol, inhibits phosphatidyl inositol synthesis as well as DNA synthesis and mitosis, but has no effect on phosphatidyl choline synthesis. When delta-hexachlorocyclohexane is added to fibroblast cultures during the first… CONTINUE READING