Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy.

@article{Agrawal2003IncreasedPS,
  title={Increased persistent sodium currents in rat entorhinal cortex layer V neurons in a post-status epilepticus model of temporal lobe epilepsy.},
  author={Newton Agrawal and Angel Alonso and David S. Ragsdale},
  journal={Epilepsia},
  year={2003},
  volume={44 12},
  pages={1601-4}
}
PURPOSE Spontaneous seizures in rats emerge several weeks after induction of status epilepticus with pharmacologic treatment or electrical stimulation, providing an animal model for human temporal lobe epilepsy. In this study, we investigated whether status epilepticus caused changes in the function of voltage-gated sodium channels in entorhinal cortex layer V neurons, a cellular group important for the genesis of limbic seizures. METHODS We induced status epilepticus in rats, by using… CONTINUE READING

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